Resveratrol
250 mg.
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Resveratrol a treatment for Diabetes?
Resveratrol , the substance in grapes and red wine, has been found by researchers at the University of Texas Southwestern Medical Center (UTSW) to lower blood sugar and improve insulin levels when injected into the brains of mice, lending hope to the idea that this compound might offer a future treatment for type 2 diabetes.
You might remember news reports on resveratrol a few years ago when this substance was identified as most likely responsible for the benefits to the heart that comes from red wine. Earlier this year, news program 60 Minutes ran a story that suggested resveratrol-based drugs might be used to slow the aging process.
But before you start downing gallons of red wine, experts warn this isn't likely to improve blood sugar and insulin levels because the helpful compound doesn't cross the blood-brain barrier very well. "We don't want to send the message that you can treat diabetes by drinking red wine," explains lead researcher Roberto Coppari, Ph.D. an assistant professor of internal medicine at US Southwestern. "Two or three glasses a day wouldn't be nearly enough for the brain to accumulate the amount of resveratrol delivered in our study. It would take many, many bottles, and clearly that wouldn't be good for you."
In earlier studies on mice, very high doses of this naturally produced molecule have been shown to protect against diabetes.
In this latest research, appearing in the December 2009 issue of the journal Endocrinology, Coppari and the team wanted to see what happens when resveratrol acts only on the brain.
They used two groups of diabetic mice, injecting a resveratrol compound directly into the brains of one group in hopes this would activate a set of proteins called sirtuins believed to be behind many of the helpful effects of restricting calories. These molecules have also shown anti-diabetic properties in earlier work on animals.
A control group of mice was given placebo injections of saline, and both groups were fed a very high fat diet all during the five week study.
The team found that the insulin levels in the resveratrol-injected mice dropped quite remarkably, going halfway to normal by the end of the study period. The insulin levels of the control mice kept going up during that same time. This is not the first study to find that resveratrol can have an impact on the consequences of eating a high fat diet.
The resveratrol shots were found to activate SIRT1 proteins in the brain, and this also helped to reduce brain inflammation related to the high calorie diets fed to the mice.
The findings suggest that the brain has a significant role in resveratrol's benefits to diabetes, and that these benefits are likely there without regard to diet or body weight.
This gives hope to the idea that new treatments for type 2 diabetes that target the brain may be possible. "The brain appears to be a major player in diabetes," Coppari points out. "The treatments we have for diabetes target other organs like the liver. The brain hasn't really been on the map."
If the current findings are confirmed by further research, the brain could become a focus of treatment not only for diabetes, but also for heart disease and obesity.
The above article is courtesy of Kirsten Whittaker, Daily Health Bulletin Editor
Resveratrol Anti-Cancerous?
Colon cancer is the third leading cause of cancer deaths among men and women in the United States. Mutations in genes leading to activation of the Wnt signaling pathway are common in colon cancer, seen in over 85% of sporadic cases. Since the Wnt pathway is critically important in the development of colon cancer, any inhibitory effects of resveratrol on this pathway are particularly relevant for scientists to explore.
Resveratrol is known to inhibit cell proliferation and induce apoptosis (early cell death) in cancer cell lines. It has colon cancer prevention activity in mouse models and possibly in humans. Scientists at the University of California have examined the effects of low concentrations of resveratrol on the Wnt signaling pathway, which is activated in over 85% of sporadic colon cancers. This study was undertaken to define whether low concentrations of resveratrol affected Wnt signaling.
Researchers conducting the study reported that low concentrations of resveratrol significantly inhibited Wnt signal throughput in colon-derived cells significantly reducing the potential for the initiation and promotion of colon cancer tumors.
- Resveratrol is a polyphenolic compound found in grapes, red wine, purple grape juice, peanuts, and some berries.
- When taken orally, resveratrol appears to be well-absorbed by humans, but its bioavailability is relatively low because it is rapidly metabolized and eliminated. However, Secrets of Eden's Resveratrol disolves in the small intestine and assures higher bioavailability.
- Scientists became interested in exploring potential health benefits of resveratrol when its presence was reported in red wine, leading to speculation that resveratrol might help explain the “French Paradox.”
- Moderate alcohol consumption has been consistently associated with 20-30% reductions in coronary heard disease risk, but it is not yet clear whether red wine polyphenols, such as resveratrol, confer any additional risk reduction.
- Although resveratrol can inhibit the growth of cancer cells in culture and in some animal models.
- Resveratrol administration has increased the lifespans of yeast, worms, fruit flies, fish, and mice fed a high-calorie diet.
In the test tube, resveratrol effectively scavenges (neutralizes) free radicals and other oxidants and inhibits low density lipid peroxidation LDL.
Resveratrol has been found to exert a number of potentially cardioprotective effects invitro, including inhibition of platelet aggregation, promotion of vasodilation by enhancing the production of NO and inhibition of inflammatory enzymes. However, the concentrations of resveratrol required to produce these effects are often higher than those that have been measured in human plasma after oral consumption of resveratrol. The results of some animal studies suggest that high oral doses of resveratrol could decrease the risk of thrombosis (clot formation) and atherosclerosis.
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The Hidden Trigger For Premature Aging
If you're over 40, your body has entered a seemingly inevitable phase, one where the health problems associated with "old age" are starting to take hold. Why is this occurring inside you? In a nutshell, your good genes are fighting a losing battle with your bad genes, making it difficult for your body to create strong, healthy, long-lasting cells.
When your cells begin to weaken, you can experience:
- Low energy levels
- Cholesterol problems
- Poor memory
- Blood sugar imbalances
- Heart problems
- Premature aging
Simply put, your cells are wearing out more and more, being overwhelmed by harmful free radicals, and self-destructing after the reproductive phase. The natural result is aging. But is this inevitable? Not if you can "turn off" your bad genes and "turn on" your good genes. Now it's possible with Secrets of Eden Resveratrol 250 mg the age-defying formula.
Add Years of Healthy Living
with Secrets of Eden Resveratrol 250 mg.
In the late 1980s, university researchers in California made an incredible discovery. When they placed lab rats on an extremely low calorie diet, the "survival genes" inside the rats were activated. These genes literally altered their rate of aging!
Twenty years later, a group of researchers at Harvard identified a powerful antioxidant—found naturally in the skin of red grapes—that could trigger these "survival genes" without calorie restrictions. It's called resveratrol.
Secrets of Eden Resveratrol 250 mg. provides optimum doses of high quality, pharmaceutical grade resveratrol—plus other anti-aging nutrients—in a single daily supplement. This superior formula helps neutralize free radical damage, promotes quicker cell repair, shuts down your sick cells, and ultimately extends the lifespan of your healthy cells.
The health benefits of Secrets of Eden Resveratrol 250 mg are supported by overwhelming scientific research. This unique product can help you promote healthy cholesterol, healthy blood pressure, healthy circulation, sharpen your mind and memory, and help promote healthy blood sugar
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